Taking aspirin daily does not reduce the the chance of heart attack or stroke and has no benefit in prolonging life free of disability, a study has found.
Aspirin-related compounds have been used for the treatment of pain since the 16th century B.C., when it was reported that people chewed on the bark of willow and papyrus.
It was first synthesised in 1898, and since the 1960s has been known to lower the risk of heart attack and stroke among those who had previously experienced heart disease or stroke
This protective capacity of aspirin was extrapolated to people who were otherwise healthy to prevent a first heart attack or stroke, despite the evidence supporting this to be sparse.
In three studies, published in the New England Journal of Medicine, researchers showed that daily low-dose aspirin (100 mg), when initiated in otherwise healthy people from age 70 onwards, has no benefit in prolonging life free of disability, or substantially reducing the risk of having a first heart attack or stroke.
Over 19,000 people in Australia and the U.S. were studied over seven years for the study called ASPREE (Aspirin in Reducing Events in the Elderly). It showed that low-dose aspirin did not prolong healthy life. Nor did it prolong life or substantially reduce the incidence of heart attack or stroke — with little difference between the placebo and aspirin groups.
“The take-home message of such a complex, large, placebo-controlled study is that Healthy older people contemplating how best to preserve their health will be unlikely to benefit from aspirin,” said John McNeil, a Professor at the Monash University in Australia.
However, it did reveal an increased risk of bleeding, a side-effect of aspirin. There was a a small increase (3.8%) in cases of serious bleeding among aspirin takers versus (2.8%) in those who took placebo.